Y-27632 dihydrochloride from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemY-27632 dihydrochloride
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Supplier Product Page
Catalog Number1254/1
Quantity1 mg (also 10 mg, 50 mg)
Brand/TrademarkTocris, a Bio-Techne Brand
Purity0.98
Molecular Weight320.26
Molecule Nametrans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
FormulaC₁₄H₂₁N₃O.2HCl
StorageDesiccate at RT

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) An in vivo neuroimmune organoid model to study human microglia phenotypesCellMay 11, 2023Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, et al.

(2) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cellsSTAR protocolsDecember 16, 2022Surendran H, Soundararajan L, Reddy K VB, Subramani J, Stoddard J, Reynaga R, Tschetter W, Ryals RC, Pal R.

(3) Transplanted human induced pluripotent stem cells- derived retinal ganglion cells embed within mouse retinas and are electrophysiologically functionaliScienceNovember 18, 2022Vrathasha V, Nikonov S, Bell BA, He J, Bungatavula Y, Uyhazi KE, Murthy Chavali VR.04–0041, Cambridge, MA, USA), and 4.2 μM Y-27632 dihydrochloride (Rock inhibitor; R&D Systems, catalog #: 1254/1, Minneapolis, MN, USA). Media was changed 24 h post-plating with RGC induction media containing: 100

(4) Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantationNature medicineApril 1, 2022Zhan L, Rao JS, Sethia N, Slama MQ, Han Z, Tobolt D, Etheridge M, Peterson QP, Dutcher CS, Bischof JC, et al.

(5) A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cellsNature methodsMay 1, 2021Chen Y, Tristan CA, Chen L, Jovanovic VM, Malley C, Chu PH, Ryu S, Deng T, Ormanoglu P, Tao D, et al.

(6) Airway basal stem cells generate distinct subpopulations of PNECsCell reportsApril 20, 2021Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, et al.Small Airway Epithelial Cell Medium (Lonza, CC-3118 or Promocell medium, C-21170) with 5–10 μM ROCKi (Tocris, 1254), 1 μM A-83–01 (Tocris, 2939), 0.1 μM DMH-1 (Tocris, 4126) and 0.5 μM CHIR99021 (Tocris, 4423). Human cells

(7) Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01Cell stem cellFebruary 4, 2021Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M, Claros N, Rosen S, Ramnarine K, Horn C, Fredrickson C, et al.

(8) Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational UseCell stem cellFebruary 4, 2021Kim TW, Piao J, Koo SY, Kriks S, Chung SY, Betel D, Socci ND, Choi SJ, Zabierowski S, Dubose BN, et al.

(9) Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics ValidationCurrent protocols in stem cell biologySeptember 1, 2020Leibel SL, McVicar RN, Winquist AM, Niles WD, Snyder EY.

(10) Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical propertiesNature materialsJuly 1, 2020Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, et al.

(11) Nuclear envelope deformation controls cell cycle progression in response to mechanical forceEMBO reportsSeptember 1, 2019Aureille J, Buffière-Ribot V, Harvey BE, Boyault C, Pernet L, Andersen T, Bacola G, Balland M, Fraboulet S, Van Landeghem L, et al.

(12) The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arresteLifeAugust 28, 2019Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF.

(13) Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinomaOncotargetAugust 27, 2019Bryant J, Batis N, Franke AC, Clancey G, Hartley M, Ryan G, Brooks J, Southam AD, Barnes N, Parish J, et al.

(14) Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactorsScientific reportsAugust 23, 2019Schwedhelm I, Zdzieblo D, Appelt-Menzel A, Berger C, Schmitz T, Schuldt B, Franke A, Müller FJ, Pless O, Schwarz T, et al.

(15) Expansion of Luminal Progenitor Cells in the Aging Mouse and Human ProstateCell reportsAugust 6, 2019Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH, Feldmar BA, Lowe MG, Garcia AJ, Wu YE, et al.

(16) Exosomes regulate neurogenesis and circuit assemblyProceedings of the National Academy of Sciences of the United States of AmericaAugust 6, 2019Sharma P, Mesci P, Carromeu C, McClatchy DR, Schiapparelli L, Yates JR 3rd, Muotri AR, Cline HT.

(17) Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potentialStem cell research & therapyAugust 5, 2019Vattulainen M, Ilmarinen T, Koivusalo L, Viiri K, Hongisto H, Skottman H.

(18) Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathwayBioscience reportsJuly 31, 2019Wang Y, Shou Z, Fan H, Xu M, Chen Q, Tang Q, Liu X, Wu H, Zhang M, Yu T, et al.

(19) Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instabilityStem cell research & therapyJuly 29, 2019Hladik D, Höfig I, Oestreicher U, Beckers J, Matjanovski M, Bao X, Scherthan H, Atkinson MJ, Rosemann M.

(20) Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarctionNature communicationsJuly 16, 2019Park SJ, Kim RY, Park BW, Lee S, Choi SW, Park JH, Choi JJ, Kim SW, Jang J, Cho DW, et al.

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(1)

9/15/2022Y-27632 for Stem Cell Cryopreservation Medium YONG MI bought Y-27632 dihydrochloride, a selective ROCK inhibitor for stem cell cryopreservation. It's diluted into 10 mM with DMSO first and used with 1:1000 when preparing cryopreservation medium. It ... Read Review